Flucloxacilline 500mg 20 Capsules

What is Flucloxacilline 500mg?

Flucloxacilline 500mg is a prescription-only oral antibiotic used to combat bacterial infections caused by penicillinase-producing staphylococci. Belonging to the beta-lactam class of medications, this semi-synthetic penicillin is specifically designed to resist enzymatic breakdown by certain resistant bacterial strains. It is commonly administered when first-line penicillin treatments prove ineffective.

Therapeutic Uses

Flucloxacilline is routinely used for the treatment of:

• Skin and soft tissue infections (SSTIs) such as cellulitis, impetigo, boils, and infected wounds.
• Osteomyelitis and other bone and joint infections.
• Respiratory tract infections, like pneumonia or lung abscesses caused by staphylococci.
• In some scenarios, surgical prophylaxis is used to prevent staphylococcal infections that can occur during procedures.

Note: MRSA (methicillin-resistant Staphylococcus aureus) and infections caused by beta-lactam-resistant organisms do not respond to flucloxacillin.

How It Works

Flucloxacilline kills bacteria by blocking the formation of their cell wall. It binds to enzymes known as penicillin-binding proteins (PBPs), preventing the bacteria from forming a stable cell wall. This causes the bacterial cells to weaken and eventually burst, leading to their death.

Because it is resistant to beta-lactamase enzymes, flucloxacillin stays active in environments where ordinary penicillins would be broken down.

Possible Side Effects

The majority of people cope well with flucloxacillin, although side effects can include:

• Gastrointestinal symptoms: nausea, vomiting, or diarrhea.
• Allergic reactions: rash, itching, hives, or rarely, anaphylaxis.
• Liver-related effects: rare cases of cholestatic jaundice or hepatitis, especially with long-term use.

If you develop jaundice (yellowing of the skin or eyes), a severe rash, or difficulty breathing (anaphylaxis), stop taking the medicine immediately and seek urgent medical attention.

Storage Instructions

• Store below 25°C in a dry place away from direct light and moisture.
• Keep capsules in their original packaging.
• Keep out of reach of children.
• Do not use after the expiry date printed on the pack.

Summary

Flucloxacilline 500mg is a penicillinase-resistant oral antibiotic suitable for treating staphylococcal infections affecting the skin, bones, and respiratory structures. Its beta-lactamase stability enhances its clinical utility, especially where resistance to standard penicillins is present. Use is restricted to prescription-only access and should follow strict medical guidance.